Don't remember the exact year, but the second town in the Baktria region just revolted to me, Maracamba, I think (or was that the first town there that revolted to me?) Greece, Macedon, and Seleucia all attacked me. I am taking your advice and focusing on one region, just fortifying the other regions. I pulled my troops out of both Baktrian towns, they were mostly peasants anyway, and am moving them toward my Black Sea towns. It is spread out already, and towns in the middle of enemy territory will only be a drain on finances, especially since I would have to have large garrisons to defend them.