Personally I'm all for legalising most drugs because it would put drug dealers out of a job and tbh if people want to portugal themselves up I feel that is their choice. Also a few currently illegal substances are rather nice.
To be fair, the only reason Tobacco and Alcohol are still legal is for the amount of money the government get from taxes. That and also the huge influx of people needing treatment and the huge amount of dealers of alcohol and tobacco it would cause...And that many members of the government (in western societies) smoke and/ or drink. And even if they didn't, criminalising such popular substances would be massively unpopular and lose them a hell of a lot of public support.