That said, it does come after massive, massive Dem gains in the past two elections; this hasn't cut into core Dem territory much, just knocked them down in most of the swing seats. In general a very good GOP night, though I suspect Republicans in both O'Donnell's and Angle's states (Delaware and Nevada respectively) will be kicking themselves for a missed opportunity to take the senate (which they easily should've done had it not been for the fact that their candidates were utterly ****ing mad).
I suspect US politics is about to grind to a halt. The senate/congress division will make it hard for either party to do anything; the most concessions the Dems can offer will be less than the the lowest the newly Tea-partied GOP will be able to accept. Prepare for deadlock, with emphais on the dead. Come 2012 it will be a presidential race of Obama VS Congress, and will ultimately depend on whether the economy's picked up and whether the republican candidate can say a sentence in the correct order without checking a crib sheet (here's looking at YOU, Sarah).
This could make things interesting, but my suspicion is that it will make them boring as hell for the next 2 years.