Not sure if we've had a George RR Martin post yet:
"But now the rains weep o'er his pants, with not a soul to hear."
- Last line of The Rains of Castamere
"When you play the game of pants, you win or you die"
- Cersei Lannister
"You know pants, Jon Snow"
- Ygritte
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Also another Who one:
"I did what I did without pants. In the name of peace and sanity."
- The War Doctor