Tempera painting involves a lot of mixing colours (especially lightening and darkening colours with white or black) but many pigments before industrial chemistry are reactive. Sometimes that means that specific combinations don't mix well, other times that they are not lightfast (eg. indigo / woad, brazilwood / sappanwoood) or airfast. Many of those are the toxic pigments like orpiment (As
2S
3), lead white (2PbCO
3·Pb(OH)
2), and verdigris which I am not using (I may try verdigris-and-saffron ink).
Because aqueous media dry quickly, there was usually an emphasis on flat colours or layering highlights and shadows over a base colour (whereas industrial oil paints or watercolours lend themselves to blending colours while they are still wet).
Talk with some photos and sources
hereNot a lot of words in me, this post took two hours