At present the quests are simply a reward for achieving a certain milestone. The Song of Orpheus, for example, rewards a player who has a certain quantity of hero pieces on the board (5 in a two player game, fewer for multiplayer games). The nature of the game means they couldn't really be location-specific. I'm not happy with the current system though. They basically reward a player for doing things they otherwise have no intention of doing, so players aren't bothering. I'm working on a new version though.
Changing the quantity of victory points is a common piece of feedback. "Perhaps each player has one specific artefact on the board worth, for them, not one but two victory points". It's an option, and could possibly be implemented in the quests. The challenge there is that the boards are currently balanced based on available VP's, so they may need re-jigging.